RO5203648 HCl Trace Amine Associated Receptor 1 Cas 1043491-54-8
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
RO5203648 HCl Trace Amine Associated Receptor 1 Cas 1043491-54-8
Chemical Information
| Product name:RO5203648 HCl | Purity:98% min |
| CAS NO:1043491-54-8 | Solubility: |
| Molecular Formula:C9H8Cl2N2O | Package:Package according to customer requirements |
| Molecular Weight:231.079 | Storage:-20 ℃ |
Remarks
RO5203648 is a TAAR1 partial agonist (Trace amine-associated receptor 1). RO5203648 showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. RO5203648 increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. RO5203648 demonstrated clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties.
RO5203648 hydrochloride is a partial agonist of Trace amine-associated receptor 1 (TAAR1).
References
1: Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace
amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents
cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol
Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015
Jun 3. PubMed PMID: 26048337.
amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents
cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol
Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015
Jun 3. PubMed PMID: 26048337.
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Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.