Leukadherin 1 cas 344897-95-6

Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.

Properties:

Boiling point: 634.7±65.0 °C(Predicted)

density: 1.50±0.1 g/cm3(Predicted)

form: powder

pka: 4.11±0.10(Predicted)

color: yellow to orange to brown

Integrin Related Products:

Cilengitide; Lifitegrast; Vedolizumab; Cilengitide trifluoroacetate; Eptifibatide; A286982

• [1] Roberts AL, et al. Clin Exp Immunol. 2016, 185(3):361-71.
• [2] Khan SQ, et al. Front Med (Lausanne). 2014, 1:45.