Dapansutrile Hydrochloride cas 54863-37-5

Dapansutrile, also known as OLT1177, is an anti-inflammatory, analgesic drug candidate. Dapansutrile is a β-sulfonyl nitrile inhibitor of the NLRP3 inflammasome that inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A. murine macrophages, human monocyte derived macrophages (HMDMs), and primary human blood neutrophils without affecting TNF-α release.

Synonyms:

1-cyano-2-methylisoindole;

3-methanesulfonylpropionitrile;

2-methyl-2H-isoindole-1-carbonitrile;

2H-Isoindole-1-carbonitrile,2-methyl;

3-(methylsulfonyl)propionitrile;

1-cyano-2-methylsulphonylethane;

NLRP3 Inhibitors Related Products:

MCC950 Sodium