Lurbinectedin cas 497871-47-3

Name: Lurbinectedin cas 497871-47-3
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:Lurbinectedin (PM01183)	Purity:98% min
CAS NO:497871-47-3	Solubility:DMSO : 20 mg/mL (25.48 mM; Need ultrasonic)
Molecular Formula:C₄₁H₄₄N₄O₁₀S	Package:Package according to customer requirements
Molecular Weight:784.874	Storage:Store at -20 ℃

Remarks

Lurbinectedin, also known as PM01183, is a synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.

DNA Alkylator/Crosslinker Related Products:

Cisplatin; Oxaliplatin; Temozolomide; Streptozocin; cyclophosphamide hydrate; Carmustine; Pepstatin A; Carboplatin

References

[1]. Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

[2]. Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.