Trabectedin Cas 114899-77-3 Synthesis Inhibitors Ecteinascidin 743
Trabectedin Cas 114899-77-3 Synthesis Inhibitors Ecteinascidin 743
| Product name:Trabectedin | Purity:98% min |
| CAS NO:114899-77-3 | Solubility:DMSO : 33.33 mg/mL (43.75 mM) |
| Molecular Formula:C39H43N3O11S | Package:Package according to customer requirements. |
| Molecular Weight:761.837 | Storage:Store at -20 ℃ |
Trabectedin (Ecteinascidin 743; ET-743) a tetrahydroisoquinoline alkaloid with potent antitumor activity isolated from Ecteinascidia turbinata. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.
Chemical Properties:
alpha: D25 +114° (c = 0.1 in methanol)
density: 1.55±0.1 g/cm3 (20 ºC 760 Torr)
pka: 9.73±0.40(Predicted)
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