ABT-538 Ritonavir CYP17 Inhibitors
Chemical Information
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Product name:Ritonavir |
Purity:99% min |
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CAS NO:155213-67-5 |
Solubility:DMSO : 25 mg/mL (34.68 mM) |
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Molecular Formula:C37H48N6O5S2 |
Package:Packaging according to customer requirements. |
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Molecular Weight:720.94 |
Storage:Store at -20℃ |
Quality control
Remarks
Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.
HIV Protease Inhibitors Related Prodcuts:
Lopinavir; Atazanavir; Panobinostat; Temsavir; Darunavir; Pepstatin A
References
[1]. Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44(2):190-4.
[2]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31.
[3]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9.
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