22-Oxacalcitriol Maxacalcitol cas 103909-75-7

Maxacalcitol, also known as 22-Oxacalcitriol, is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis. Maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.

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Falecalcitriol; Lexacalcitol; Tisocalcitate; Seocalcitol; Alfacalcidol; Eldecalcitol; Paricalcitol; Calcifediol monohydrate; Calcitriol; Calcipotriol; Doxercalciferol; Inecalcitol

[1]. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.

[2]. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.