Doxercalciferol cas 54573-75-0

Doxercalciferol, also known as 1-hydroxy Vitamin D2, is a synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion.

Properties:
Appearance & Physical State: White crystalline powder
Density: 1.01 g/cm3
Melting Point: 138-140ºC
Boiling Point: 538.7ºC at 760 mmHg
Flash Point: 224ºC
Refractive Index: 1.541
Storage Condition: Desiccate at -20ºC

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Falecalcitriol; Lexacalcitol; Tisocalcitate; Seocalcitol; Alfacalcidol; Eldecalcitol; Paricalcitol; Calcifediol monohydrate; Calcitriol; Maxacalcitol; Calcipotriol; Inecalcitol

[1]. Noonan W, et al. Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol Dial Transplant. 2008 Dec;23(12):3824-30.

[2]. Wang XX, et al. Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism. Am J Physiol Renal Physiol. 2011 Mar;300(3):F801-10.