Alfatradiol Estradiol 17 Alpha Estradiol 5α Reductase Inhibitor Cas 57-91-0
Alfatradiol Estradiol 17 Alpha Estradiol 5α Reductase Inhibitor Cas 57-91-0
| Product name:Alfatradiol Estradiol | Purity:98% min |
| CAS NO:57-91-0 | Solubility:DMSO : 103.3 mg/mL (379.25 mM) |
| Molecular Formula:C18H24O2 | Package:Package according to customer requirements |
| Molecular Weight:272.382 | Storage:Store at -20℃ |
Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
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[1]. Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41(11):1186-9.
[2]. Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.
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