FK520 API Cas 104987-12-4

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein.

Properties:

Appearance & Physical State: White Solid

Density: 1.19 g/cm3

Boiling Point: 868.3ºC at 760 mmHg

Melting Point: 153-157ºC

Flash Point: 478.9ºC

Refractive Index: 1.543

Anti-infection Inhibitors Related Prodcuts:

Sulfathiazole sodium; Sulfathiazole; Tofacitinib citrate; Phthalylsulfathiazole; Olsalazine Sodium; Sulfamethoxypyridazine; Buparvaquone; Sulbactam

[1]. Hatanaka H, Kino T, Miyata S, FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601.

[2]. Teutsch M, Higer M, Wang D, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. Int Immunol. 1995 Mar;7(3):381-92.

[3]. Mollison KW, Fey TA, Krause RA, Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998 Feb 6;125(2-3):169-81.