Pitolisant Oxalate DNA Synthesis Inhibitors

Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).

Histamine Receptor Inhibitors Related Products:

Pitolisant; Loratadine; Bepotastine; Ciproxifan; Ciproxifan Maleate; Fexofenadine hydrochloride; Hydroxyzine dihydrochloride; Azatadine maleate; Betahistine dihydrochloride; Ebastine; Pitolisant hydrochloride

[1]. Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.

[2]. Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9.