DNA Synthesis Inhibitors

Chemical Information Product name:Nelarabine Purity:98% min CAS NO:121032-29-9 Solubility:DMSO : 9.8 mg/mL (32.97 mM) Molecular Formula:C11H15N5O5 Package:Packaging according to customer requirements Molecular Weight:297.27 Storage:Store at -20℃ Quality control COA Remarks Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic

Chemical Information Product name:Temozolomide Purity:98% min CAS NO:85622-93-1 Solubility:DMSO : 20.83 mg/mL (107.29 mM) Molecular Formula:C6H6N6O2 Package:Packaging according to customer requirements Molecular Weight:194.15 Storage:Store at 2-8ºC Quality control COA Remarks Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and

Chemical Information Product name:ENMD-2076 Purity:98% min CAS NO:934353-76-1 Solubility:DMSO : ≥ 31 mg/mL (82.56 mM) Molecular Formula:C21H25N7 Package:Package according to customer requirements Molecular Weight:375.470 Storage:Store at -20℃ Remarks ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase

Chemical Information Product name:Streptozocin Purity:98% min CAS NO:18883-66-4 Solubility:DMSO : ≥ 30 mg/mL (113.11 mM) Molecular Formula:C8H15N3O7 Package:Packaging according to customer requirements Molecular Weight:C27H41NO8 Storage:Store at -20℃ Remarks Streptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to

Chemical Information Product name:TMP269 Purity:98% min CAS NO:1314890-29-3 Solubility:DMSO: ≥ 41 mg/mL Molecular Formula:C25H21F3N4O3S Package:Package according to customer requirements Molecular Weight:514.519 Storage:Store at -20℃ Quality control COA Remarks TMP269 has no impact on the mitochondrial activity and/or the viability of human CD4+ T cells at 10 μM, and may be used as tools to identify the endogenous substrates of the class IIa HDAC enzymes. In IEC-18 intestinal

Chemical Information Product name:Fosbretabulin disodium Purity:98% min CAS NO:168555-66-6 Solubility:DMSO : < 1 mg/mL; H2O : 4.5 mg/mL (10.22 mM) Molecular Formula:C18H19Na2O8P Package:Package according to customer requirements Molecular Weight:440.292 Storage:Store at -20℃ Remarks Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular

Chemical Information Product name:Miriplatin Purity:98% min CAS NO:141977-79-9 Solubility:DMF : < 1 mg/mL; H2O : < 0.1 mg/mL Molecular Formula:C34H68N2O4Pt Package:Package according to customer requirements Molecular Weight:763.993 Storage:Store at -20℃ Remarks Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin is a lipophilic platinum complex that can be easily suspended in Lipiodol and

Chemical Information Product name:Oxaliplatin Purity:98% min CAS NO:61825-94-3 Solubility:DMF : 17.5 mg/mL (44.05 mM) Molecular Formula:C8H14N2O4Pt Package:Package according to customer requirements. Molecular Weight:397.286 Storage:Store at -20℃ Quality control COA Remarks Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group

Chemical Information Product name:Mizoribine Purity:98% min CAS NO:50924-49-7 Solubility:DMSO: ≥ 35 mg/mL Molecular Formula:C9H13N3O6 Package:Package according to customer requirements Molecular Weight:259.2160 Storage:Store at -20℃ Quality control COA Remarks Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum.

Chemical Information Product name:Resminostat hydrochloride Purity:98% min CAS NO:1187075-34-8 Solubility:DMSO : ≥ 50 mg/mL (129.58 mM) Molecular Formula:C16H20ClN3O4S Package:Package according to customer requirements Molecular Weight:385.866 Storage:Store at -20℃ Remarks Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.

Chemical Information Product name:Irinotecan HCl trihydrate Purity:98% min CAS NO:136572-09-3 Solubility:DMSO; H2O: 1.52 mg/mL Molecular Formula:C33H45ClN4O9 Package:Package according to customer requirements Molecular Weight:677.185 Storage:Store at -20℃ Quality control COA Remarks Irinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

Chemical Information Product name:Capecitabine Purity:98% min CAS NO:154361-50-9 Solubility:DMSO : 100 mg/mL (278.28 mM) Molecular Formula:C15H22FN3O6 Package:Packaging according to customer requirements Molecular Weight:359.35 Storage:Store at -20℃ Quality control COA Remarks Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic

Chemical Information Product name:Lomustine Purity:98% min CAS NO:13010-47-4 Solubility:DMSO : ≥ 100 mg/mL (427.90 mM) Molecular Formula:C9H16ClN3O2 Package:Packaging according to customer requirements Molecular Weight:233.7 Storage:Store at -20℃ Quality control COA Remarks Lomustine is a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in

Chemical Information Product name:Triapine Purity:99% min CAS NO:143621-35-6 Solubility:DMSO : ≥ 47 mg/mL (240.73 mM) Molecular Formula:C7H9N5S Package:Package according to customer requirements Molecular Weight:195.245 Storage:-20℃ Remarks Triapine, also known as 3-AP and OCX-191, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the

Chemical Information Product name:ENMD-2076 Tartrate Purity:98% min CAS NO:1291074-87-7 Solubility:Soluble in DMSO Molecular Formula:C25H31N7O6 Package:Package according to customer requirements. Molecular Weight:525.557 Storage:Store at -20℃ Remarks ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD

Chemical Information Product name:Carmustine Purity:98% min CAS NO:154-93-8 Solubility:DMSO : ≥ 35 mg/mL (163.51 mM) Molecular Formula:C5H9Cl2N3O2 Package:Packaging according to customer requirements Molecular Weight:214.05 Storage:Store at -20℃ Quality control COA| NMR| HPLC Remarks Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a medication used mainly for chemotherapy and sometimes for immunosuppression before organ transplantation. It is a nitrogen mustard β

Chemical Information Product name:Teniposide Purity:98% min CAS NO:29767-20-2 Solubility:DMSO : ≥ 30 mg/mL (45.69 mM) Molecular Formula:C32H32O13S Package:Package according to customer requirements. Molecular Weight:656.654 Storage:Store at -20℃ Quality control COA Remarks Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and

Chemical Information Product name:Nelarabine Purity:98% min CAS NO:121032-29-9 Solubility:DMSO : 9.8 mg/mL (32.97 mM) Molecular Formula:C11H15N5O5 Package:Packaging according to customer requirements Molecular Weight:297.27 Storage:Store at -20℃ Quality control COA Remarks Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic

Chemical Information Product name:Cisplatin Purity:98% min CAS NO:15663-27-1 Solubility:DMSO : 200 mg/mL (666.56 mM) Molecular Formula:Cl2H6N2Pt Package:Packaging according to customer requirements Molecular Weight:300.05 Storage:Store at -20℃ Remarks Cisplatin induces cytotoxic by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. Cisplatin (30 mM)

Chemical Information Product name:Tanespimycin (17-AAG) Purity:98% min CAS NO:75747-14-7 Solubility:DMSO : ≥ 55 mg/mL (93.91 mM) Molecular Formula:C31H43N3O8 Package:Package according to customer requirements Molecular Weight:585.688 Storage:Store at -20℃ Remarks Tanespimycin, also known as 17-AAG, is an orally bioavailable, small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and