DNA Synthesis Inhibitors

Chemical Information Product name:KU-55933 Purity:98% min CAS NO:587871-26-9 Solubility:DMSO : 80 mg/mL (202.28 mM) Molecular Formula:C21H17NO3S2 Package:Package according to customer requirements Molecular Weight:395.495 Storage:Store at -20℃ Remarks KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation

Chemical Information Product name:Topotecan Hydrochloride Purity:98% min CAS NO:119413-54-6 Solubility:DMSO : 15.3 mg/mL (33.41 mM) Molecular Formula:C23H24ClN3O5 Package:Package according to customer requirements. Molecular Weight:457.907 Storage:Store at -20℃ Quality control COA Remarks Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent

Chemical Information Product name:NSC-118218 Fludarabine Purity:98% min CAS NO:21679-14-1 Solubility:DMSO : ≥ 160 mg/mL (560.95 mM) Molecular Formula:C10H12FN5O4 Package:Package according to customer requirements Molecular Weight:285.232 Storage:Store at -20℃ Remarks Fludarabine is an adenosine analong, DNA chain terminator, and inhibitor of ribonucleotide reductase, DNA ligase, DNA primase, and adenoside A1 receptors. It is use to treat leukemias and graft-versus host

Chemical Information Product name:Ellipticine hydrochloride Purity:98% min CAS NO:5081-48-1 Solubility:5.8 mg/mL (20.51 mM) Molecular Formula:C17H15ClN2 Package:Package according to customer requirements Molecular Weight:282.767 Storage:Store at -20℃ Remarks Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is an alkaloid first extracted from trees of the species Ochrosia elliptica and Rauvolfia sandwicensis,[5][6] which inhibits the

Chemical Information Product name:Dexrazoxane hydrochloride Purity:98% min CAS NO:149003-01-0 Solubility:DMSO : 50 mg/mL; H2O : 20 mg/mL Molecular Formula:C11H17ClN4O4 Package:Package according to customer requirements Molecular Weight:304.73 Storage:Store at -20℃ Remarks Dexrazoxane HCl is a cytoprotective agent. It acts by penetrating cell membranes and interferring with iron-mediated free radical generation. Properties: Melting Point: 193ºC Boiling Point: 531.5ºC at 760

Chemical Information Product name:BMS-247615 TAS-103 Purity:98% min CAS NO:174634-08-3 Solubility:Soluble in DMSO Molecular Formula:C20H19N3O2 Package:Package according to customer requirements Molecular Weight:333.384 Storage:Store at -20℃ Remarks TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest

Chemical Information Product name:Maytansinoid DM1 Mertansine Purity:98% min CAS NO:139504-50-0 Solubility:DMSO : ≥ 83.33 mg/mL (112.87 mM) Molecular Formula:C35H48ClN3O10S Package:Package according to customer requirements Molecular Weight:738.288 Storage:Store at -20℃ Remarks Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with an SPP (N

Chemical Information Product name:10-Hydroxycamptothecin Purity:98% min CAS NO:19685-09-7 Solubility:DMSO: ≥ 39 mg/mL Molecular Formula:C20H16N2O5 Package:Package according to customer requirements Molecular Weight:364.351 Storage: Store at -20℃ Remarks (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing

Chemical InformationProduct name:IrinotecanPurity:98% minCAS NO:97682-44-5Solubility:DMSO : 25 mg/mL (42.61 mM)Molecular Formula:C33H38N4O6Package:Packaging according to customer requirementsMolecular Weight:586.678Storage:Store at -20℃RemarksIrinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I. Irinotecan induces similar amounts of cleavable complexes at its IC50 in LoVo cells and HT-29 cell lines. SN-38 induces a

Chemical Information Product name:Clevudine Purity:98% min CAS NO:163252-36-6 Solubility:DMSO : 100 mg/mL (384.29 mM) Molecular Formula:C10H13FN2O5 Package:Package according to customer requirements Molecular Weight:260.219 Storage:Store at -20℃ Remarks Clevudine, also known as L-FMAU, is an antiviral used in the treatment of Hepatitis B. Clevudine is differentiated from other oral agents by an unusual activation pathway to the biochemically active triphosphate, a mechanism

Chemical Information Product name:camptothecin Purity:98% min CAS NO:7689-03-4 Solubility:DMSO: 20.66 mg/mL (Need warming) Molecular Formula:C20H16N2O4 Package:Package according to customer requirements Molecular Weight:348.352 Storage: Store at -20℃ Remarks Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for

Chemical Information Product name:Gemcitabine HCL Purity:98% min CAS NO:122111-03-9 Solubility:H2O : ≥ 66.66 mg/mL (222.45 mM) Molecular Formula:C9H12ClF2N3O4 Package:Package according to customer requirements Molecular Weight:299.659 Storage:Store at -20℃ Remarks Gemcitabine hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites

Chemical Information Product name:Nexturastat A Purity:98% min CAS NO:1403783-31-2 Solubility:DMSO : ≥ 56 mg/mL (164.03 mM) Molecular Formula:C19H23N3O3 Package:Package according to customer requirements Molecular Weight:341.404 Storage:Store at -20℃ Remarks Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Nexturastat A possesses antiproliferative effects against melanoma

Chemical InformationProduct name:CW069Purity:98% minCAS NO:1594094-64-0Solubility:DMSO : ≥ 52 mg/mL (103.93 mM)Molecular Formula:C23H21IN2O3Package:Package according to customer requirementsMolecular Weight:500.329Storage:Store at -20℃Quality controlCOARemarksCW069 is an allosteric inhibitor of HSET. CW069 showed marked activity against HSET in vitro. The inhibitor induced multipolar mitoses only in cells containing supernumerary centrosomes. CW069 therefore constitutes a

Chemical Information Product name:GSK2606414 Purity:98% min CAS NO:1337531-36-8 Solubility:DMSO : ≥ 31 mg/mL (68.67 mM) Molecular Formula:C24H20F3N5O Package:Package according to customer requirements. Molecular Weight:451.444 Storage:Store at -20℃ Quality control COA Remarks GSK2606414 is an orally available, potent, and selective PERK inhibitor. GSK2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)

Chemical Information Product name:Elimusertib (BAY-1895344) Purity:98% min CAS NO:1876467-74-1 Solubility:DMSO : 5.4 mg/mL (14.38 mM) Molecular Formula:C20H21N7O Package:Package according to customer requirements. Molecular Weight:375.427 Storage:Store at -20℃ Remarks Elimusertib (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib has anti-tumor activity. Elimusertib can be used for the research of solid tumors and lymphomas.

Chemical Information Product name:K-858 Racemic Purity:98% min CAS NO:72926-24-0 Solubility:DMSO : 100 mg/mL (360.57 mM); H2O : < 0.1 mg/mL Molecular Formula:C13H15N3O2S Package:Package according to customer requirements Molecular Weight:277.342 Storage:Store at +4°C Remarks K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest

Chemical Information Product name:cyclophosphamide hydrate Purity:98% min CAS NO:6055-19-2 Solubility:DMSO : ≥ 38 mg/mL (136.15 mM) Molecular Formula:C7H17Cl2N2O3P Package:Package according to customer requirements Molecular Weight:279.101 Storage:Store at 2-8ºC Quality control COA Remarks Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. Properties: Appearance & Physical

Chemical Information Product name:NSC 375101D nedaplatin Purity:98% min CAS NO:95734-82-0 Solubility:H2O : 13.6 mg/mL (44.86 mM) Molecular Formula:C2H8N2O3Pt Package:Package according to customer requirements Molecular Weight:303.175 Storage:Store at -20℃ Remarks Nedaplatin (INN, marketed under the tradename Aqupla) is a platinum-based antineoplastic drug which is used for cancer chemotherapy. It produces less nausea, vomiting and nephrotoxicity than other platinum-containing

Chemical Information Product name:Flupirtine Maleate Salt Purity:98% min CAS NO:75507-68-5 Solubility:DMSO : ≥ 40 mg/mL (95.15 mM) Molecular Formula:C19H21FN4O6 Package:Package according to customer requirements Molecular Weight:420.392 Storage:Store at -20℃ Remarks Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Properties: Appearance & Physical State: off-white Crystalline powder Density: 1.35 g