Adapalene cas 106685-40-9

Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.

Properties:

Appearance & Physical State: white to off-white crystalline powder

Density: 1.233 g/cm3

Boiling Point: 606.3ºC at 760 mmHg

Melting Point: 319-322ºC

Flash Point: 205.9ºC

Refractive Index: 1.654

Vapor Pressure: 1.49E-15mmHg at 25°C

Retinoid Receptor inhibitor Related Products:

Fenretinide; Retinoic acid; Acitretin; Tazarotene; Tamibarotene; AM580; Bexarotene

[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7.

[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.