BKM120 Buparlisib NVP-BKM-120 Cas 944396-07-0
BKM120 Buparlisib NVP-BKM-120 Cas 944396-07-0
| Product name:BKM120 Buparlisib | Purity:98% min |
| CAS NO:944396-07-0 | Solubility:DMSO : ≥ 100 mg/mL (243.67 mM) |
| Molecular Formula:C18H21F3N6O2 | Package:Package according to customer requirements. |
| Molecular Weight:410.394 | Storage:Store at -20℃ |
Buparlisib, also known as BKM120; NVP-BKM-120, is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway.
Related Products:
Idelalisib; Almorexant HCL; IC-87114; Pictilisib; Pictilisib mesylate; XL147; PIK-90; Omipalisib; TG100-115; A66; AS-252424; GSK2636771; CH5132799; 3-methyladenine; AS-604850
[1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9.
[2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706.
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