GSK3787 cas 188591-46-0

Name: GSK3787 cas 188591-46-0
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:GSK3787	Purity:98% min
CAS NO:188591-46-0	Solubility:DMSO : ≥ 50 mg/mL (127.30 mM); H2O : < 0.1 mg/mL
Molecular Formula:C₁₅H₁₂ClF₃N₂O₃S	Package:Package according to customer requirements
Molecular Weight:392.781	Storage:Store at -20℃

Remarks

GSK-3787 is a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist with good pharmacokinetic properties. GSK3787 can antagonize PPARbeta/delta in vivo, thus providing a new strategy to delineate the functional role of a receptor with great potential as a therapeutic target for the treatment and prevention of disease.

PPAR Inhibitors Related Prodcuts:

GW9662; Fenofibric acid; Bezafibrate

References

[1]. Shearer BG, et al. Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J Med Chem. 2010 Feb 25;53(4):1857-61.

[2]. Palkar PS, et al. Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol. 2010 Sep;78(3):419-30.