MLN-4760 cas 305335-31-3

Name: MLN-4760 cas 305335-31-3
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:MLN-4760	Purity:98% min
CAS NO:305335-31-3	Solubility:DMSO : 100 mg/mL (233.48 mM; Need ultrasonic)
Molecular Formula:C₁₉H₂₃Cl₂N₃O₄	Package:Package according to customer requirements
Molecular Weight:428.31	Storage:Store at -20℃

Remarks

MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

References

[1]. Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

[2]. Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33.