Custom Chemical Synthesis

API-1 NSC 177223 Custom Chemical Synthesis Cas 36707-00-3 Chemical Information Product name:API-1 NSC 177223 Purity:98% min CAS NO:36707-00-3 Solubility: Molecular Formula:C13H15N5O6 Package:Package according to customer requirements Molecular Weight:337.28 Storage:-20℃ Remarks API-1 is a potent Akt inhibitor, which induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1

2 Sulfamidobenzoic Acid Custom Chemical Synthetic Cas 632-24-6 Chemical Information Product name:2-Sulfamidobenzoic acid Purity:98% min CAS NO:632-24-6 Solubility: Molecular Formula:C7H7NO4S Package:Package according to customer requirements Molecular Weight:201.20 Storage:-20 ℃ Remarks Synonyms: 2-Sulfamidobenzoic acid; 2-Sulfamoyl-benzoesaeure; Benzoic acid, 2-(aminosulfonyl)-; 2-CARBOXY PHENYLSULFAMIDE; 2-Carboxybenzenesulfonamide; 2-sulfamoyl-benzoic acid; o-carboxybenzen

Ziconotide Acetate Cas 107452-89-1 Analgesic Agent Chemical Information Product name:Ziconotide acetate Purity:98% min CAS NO:107452-89-1 Solubility:Soluble in DMSO Molecular Formula:C102H172N36O32S7 Package:Package according to customer requirements Molecular Weight:2639.13 Storage:-20℃ Remarks Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part

OTSSP167 HCl orally MELK Inhibitor Cas 1431698-10-0 Chemical Information Product name:OTSSP167 HCl Purity:98% min CAS NO:1431698-10-0 Solubility:DMSO : 33.33 mg/mL (63.62 mM) Molecular Formula:C25H29Cl3N4O2 Package:Package according to customer requirements Molecular Weight:523.88 Storage:-20℃ Remarks OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration,

Chemical Information Product name:Decapeptide-12 Purity:98% min CAS NO:137665-91-9 Solubility:Soluble in DMSO Molecular Formula:C66H91N17O17 Package:Package according to customer requirements Molecular Weight:1395.52 Storage:-20ºC Remarks Synonyms: Decapeptide-12/ Lumixyl; Decapeptide-12 lumixyl / cosmetic peptide; L-Tyrosine, L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl- Properties: density: 1.51±0.1 g/cm3(Predicted) pka: 3.07±0.10

Chemical Information Product name:1-Bromo-2,4,5-trifluorobenzene Purity:98% min CAS NO:327-52-6 Solubility:Soluble in DMSO Molecular Formula:C36H18 Package:Package according to customer requirements. Molecular Weight:450.528 Storage:-20ºC Remarks 1-Bromo-2,4,5-trifluorobenzene is a reactant that is used in the synthesis of fluorinated benzophenones, xanthones, acridones and thioxanthones by iterative nucleophilic aromatic substitution. Synonyms: 2,4,5-trifluorophenyl bromide;

RO2959 Hydrochloride CRAC Channel Inhibitor Cas 1219927-22-6 Chemical Information Product name:RO2959 hydrochloride Purity:98% min CAS NO:1219927-22-6 Solubility: Molecular Formula:C21H20ClF2N5OS Package:Package according to customer requirements Molecular Weight:463.93 Storage:-20℃ Remarks RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by

Chemical Information Product name:Benzamidine hydrochloride Purity:98% min CAS NO:1670-14-0 Solubility:DMSO : 100 mg/mL (638.53 mM) Molecular Formula:C7H9ClN2 Package:Package according to customer requirements. Molecular Weight:156.613 Storage:-20ºC Remarks Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively. Synonyms: BENZAMIDE HCL

RG7834 S Isomer RO7020322 Custom Chemical Synthetic Cas 2072057-17-9 Chemical Information Product name:RG7834 S-isomer Purity:98% min CAS NO:2072057-17-9 Solubility: Molecular Formula:C22H27NO6 Package:Package according to customer requirements Molecular Weight:401.453 Storage:-20 ℃ Remarks RG7834 (RO 7020322) is a highly selective and orally bioavailable inhibitor of HBV. RG7834 potently inhibits HBsAg, HBeAg, and HBV DNA, with IC50 of 2.8 nM, 2.6 nM, and 3.2 nM, respectivel

Chemical Information Product name:GF120918 Elacridar Purity:98% min CAS NO:143664-11-3 Solubility:DMSO : 5 mg/mL (8.87 mM) Molecular Formula:C34H33N3O5 Package:Package according to customer requirements Molecular Weight:563.643 Storage:-20°C Remarks Elacridar, also known as GF120918A, is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of

GW280264X Custom Chemical Synthesis ADAM17 inhibitor Cas 866924-39-2 Chemical Information Product name:GW280264X Purity:98% min CAS NO:866924-39-2 Solubility: Molecular Formula:C28H41N5O6S Package:Package according to customer requirements Molecular Weight:575.72 Storage:-20℃ Remarks GW280264X is an ADAM17 inhibitor. References 1: Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS, D'Amore PA. ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced

Chemical Information Product name:Nisoxetine hydrochloride Purity:98% min CAS NO:57754-86-6 Solubility: Molecular Formula:C17H22ClNO2 Package:Package according to customer requirements Molecular Weight:307.815 Storage:-20℃ Remarks Nisoxetine hydrochloride is a potent and selective noradrenaline transporter (NET) inhibitor with Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic that blocks voltage-gated sodium channels. References [1]. Béïque JC,

ML-246 Metarrestin Custom Chemical Synthesis Cas 1443414-10-5 Chemical Information Product name:Metarrestin (ML246) Purity:98% min CAS NO:1443414-10-5 Solubility:DMSO : 31.25 mg/mL (65.84 mM) Molecular Formula:C31H30N4O Package:Package according to customer requirements. Molecular Weight:474.596 Storage:-20 ℃ Remarks Metarrestin (ML246) is an orally active, specific perinucleolar compartment inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I

Syn Ake Acetate Custom Chemical Synthesis Cas 823202-99-9 Chemical Information Product name:Syn-Ake acetate Purity:98% min CAS NO:823202-99-9 Solubility:Soluble in DMSO Molecular Formula:C19H29N5O3.2(C2H4O2) Package:Package according to customer requirements Molecular Weight:495.58 Storage:-20ºC Remarks Dipeptide diaminobutyroyl benzylamide is a biomimetic peptide and a muscarinic acetylcholine receptor antagonist.1 It mimics the action of the temple viper (T. wagleri) venom

Pitolisant Hydrochloride Custom Chemical Synthesis Cas 903576-44-3 Chemical Information Product name:Pitolisant hydrochloride Purity:98% min CAS NO:903576-44-3 Solubility:DMSO : ≥ 43 mg/mL (129.40 mM) Molecular Formula:C17H27Cl2NO Package:Package according to customer requirements Molecular Weight:332.308 Storage:-20 ℃ Remarks Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). Chemical

RO5203648 HCl Trace Amine Associated Receptor 1 Cas 1043491-54-8 Chemical Information Product name:RO5203648 HCl Purity:98% min CAS NO:1043491-54-8 Solubility: Molecular Formula:C9H8Cl2N2O Package:Package according to customer requirements Molecular Weight:231.079 Storage:-20 ℃ Remarks RO5203648 is a TAAR1 partial agonist (Trace amine-associated receptor 1). RO5203648 showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinet

Chemical Information Product name:PLB-1001 Bozitinib Purity:98% min CAS NO:1440964-89-5 Solubility:DMSO :85 mg/mL (200.29 mM) Molecular Formula:C20H15F3N8 Package:Package according to customer requirements Molecular Weight:424.382 Storage:-20 ℃ Remarks Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical

Chemical Information Product name:Myristoyl tetrapeptide-12 Purity:98% min CAS NO:959610-24-3 Solubility:Soluble in DMSO Molecular Formula:C32H63N7O5 Package:Package according to customer requirements Molecular Weight:625.89 Storage:-20ºC Remarks Chemical Name: N2-(1-Oxotetradecyl)-L-lysyl-L-alanyl-L-lysyl-L-alaninamide Synonyms: L-Alaninamide, N2-(1-oxotetradecyl)-L-lysyl-L-alanyl-L-lysyl-; Properties: Boiling point: 932.2±65.0 °C(Predicted) density: 1.060±0.06 g/cm3

GSK3 Inhibitor XIII Aminopyrazole ATP Competitive Inhibitor Cas 404828-08-6 Chemical Information Product name:GSK3 Inhibitor XIII Purity:98% min CAS NO:404828-08-6 Solubility: Molecular Formula:C18H15N5 Package:Package according to customer requirements Molecular Weight:301.345 Storage:-20 ℃ Remarks GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM. It inhibits

RY785 Kv2-IN-A1 Custom Chemical Synthetic Cas 689297-68-5 Chemical Information Product name:RY785 Kv2-IN-A1 Purity:98% min CAS NO:689297-68-5 Solubility: Molecular Formula:C20H17ClN4OS Package:Package according to customer requirements Molecular Weight:396.89 Storage:-20 ℃ Remarks RY785 (Kv2-IN-A1) is an inhibitor of Kv2.1 and Kv2.2.