Synthesis Inhibitors

Chemical Information Product name:CGS-21680 Purity:98% min CAS NO:120225-54-9 Solubility:10 mM in DMSO Molecular Formula:C23H29N7O6 Package:Package according to customer requirements Molecular Weight:499.520 Storage:Store at -20℃ Remarks CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin. The chemical is currently used by researchers interested in studying neuronal

Chemical Information Product name:L-165041 Purity:98% min CAS NO:79558-09-1 Solubility:DMSO : 50 mg/mL (124.24 mM) Molecular Formula:C22H26O7 Package:Package according to customer requirements Molecular Weight:402.438 Storage:Store at -20℃ Remarks L-165041, also known as L-165,041, is a potent and selective agonist of the nuclear receptor PPARβ/δ (Ki = 9 nM, EC50 = ~500 nM for hPPARβ/δ). L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a

Chemical Information Product name:Tacrolimus monohydrate Purity:98.0% min CAS NO:109581-93-3 Solubility:DMSO : 100 mg/mL (121.65 mM; Need ultrasonic) Molecular Formula:C44H71NO13 Package:Package according to customer requirements Molecular Weight:822.033 Storage:Store at -20℃ Remarks Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal

Chemical Information Product name:MLN-4760 Purity:98% min CAS NO:305335-31-3 Solubility:DMSO : 100 mg/mL (233.48 mM; Need ultrasonic) Molecular Formula:C19H23Cl2N3O4 Package:Package according to customer requirements Molecular Weight:428.31 Storage:Store at -20℃ Remarks MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidas

Chemical Information Product name:Sparsentan (RE-021) Purity:98.0% min CAS NO:254740-64-2 Solubility:DMSO : 250 mg/mL (421.76 mM; Need ultrasonic) Molecular Formula:C32H40N4O5S Package:Package according to customer requirements Molecular Weight:592.749 Storage:Store at -20℃ Remarks Sparsentan, also known as RE-021, PS433540 and DARA-a, is a Dual angiotensin II and endothelin A receptor antagonist. Retrophin intends to develop RE-021 for orphan indications of severe kidney

Chemical Information Product name:LY-404187 Purity:98% min CAS NO:211311-95-4 Solubility:Soluble in DMSO Molecular Formula:C19H22N2O2S Package:Package according to customer requirements Molecular Weight:342.455 Storage:Store at -20℃ Remarks LY-404187 is an ampakine, AMPA receptor potentiator. LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the

Chemical Information Product name:sitafloxacin isomer III(RRS) Purity:98% min CAS NO:127254-10-8 Solubility:DMSO Molecular Formula:C19H18ClF2N3O3 Package:Package according to customer requirements Molecular Weight:409.814 Storage:Store at -20℃ Remarks Properties: Density: 1.63 g/cm3 Boiling Point: 629.2ºC at 760 mmHg Flash Point: 334.3ºC Related Prodcuts: sitafloxacin isomer I(SSR); sitafloxacin isomer II(RSR); Sitafloxacin Hydrate

Chemical Information Product name:sitafloxacin isomer II(RSR) Purity:98% min CAS NO:1271199-06-8 Solubility:Soluble in DMSO Molecular Formula: Package:Package according to customer requirements Molecular Weight: Storage:Store at -20℃ Quality control Remarks sitafloxacin isomer II(RSR) cas 1271199-06-8 Related Prodcuts: sitafloxacin isomer I(SSR); sitafloxacin isomer III(RRS); Sitafloxacin Hydrate

Chemical Information Product name:LY-450108 Purity:98% min CAS NO:376594-67-1 Solubility:DMSO : ≥ 50 mg/mL (126.12 mM) Molecular Formula:C19H22F2N2O3S Package:Package according to customer requirements Molecular Weight:396.451 Storage:Store at -20℃ Remarks LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. IC50 value: Target: AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic

Chemical Information Product name:JNJ-632 Purity:98% min CAS NO:1572510-42-9 Solubility:DMSO : 125 mg/mL (330.32 mM) Molecular Formula:C18H19FN2O4S Package:Package according to customer requirements. Molecular Weight:378.4184 Storage:Store at -20℃ Remarks JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. Administration of JNJ-632 in HBV genotype D infected chimeric mice, resulted in a 2.77 log reduction

Chemical Information Product name:Marimastat Purity:98% min CAS NO:154039-60-8 Solubility:DMSO : 100 mg/mL (301.74 mM) Molecular Formula:C15H29N3O5 Package:Package according to customer requirements Molecular Weight:331.41 Storage:Store at -20℃ Remarks Marimastat, aslo known as BB-2516 and TA-2516, is an orally-active synthetic hydroxamate and inhibitor of matrix metalloproteinases with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the

Chemical Information Product name:PTC-028 Purity:99% min CAS NO:1782970-28-8 Solubility:DMSO : 125 mg/mL (308.40 mM) Molecular Formula:C19H12F5N5 Package:Package according to customer requirements Molecular Weight:405.332 Storage:-20℃ Remarks PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification. In vivo, orally administered PTC-028, as a single agent, exhibits significant antitumor activity comparable with the standard

Chemical Information Product name:AF64394 Purity:98% min CAS NO:1637300-25-4 Solubility:DMSO : ≥ 125 mg/mL (317.36 mM) Molecular Formula:C21H20ClN5O Package:Package according to customer requirements Molecular Weight:393.87 Storage:-20℃ Quality control COA Remarks AF64394 is a selective GPR3 Inverse Agonist. It is the first small molecule inhibitor of GPR3 receptor function. AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of

Chemical Information Product name:AKTIV Akt Inhibitor IV Purity:98% min CAS NO:681281-88-9 Solubility:Soluble in DMSO Molecular Formula:C31H27IN4S Package:Package according to customer requirements Molecular Weight:614.542 Storage:Store at -20℃ Remarks Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a

Chemical Information Product name:NVS-PAK1-1 Purity:98% min CAS NO:1783816-74-9 Solubility:DMSO : ≥ 125 mg/mL (260.45 mM) Molecular Formula:C23H25ClF3N5O Package:Package according to customer requirements Molecular Weight:479.93 Storage:Store at 2-8°C Remarks NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM. References [1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med

Chemical Information Product name:Milvexian (BMS-986177) Purity:98.0% min CAS NO:1802425-99-5 Solubility:Soluble in DMSO Molecular Formula:C28H23Cl2F2N9O2 Package:Package according to customer requirements Molecular Weight:626.44 Storage:Store at -20℃ Remarks Milvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively. Synonyms: 11,15

Chemical Information Product name:β-Nicotinamide mononucleotide Purity:98% min CAS NO:1094-61-7 Solubility:H2O : 83.33 mg/mL (249.33 mM) Molecular Formula:C11H15N2O8P Package:Package according to customer requirements. Molecular Weight:334.219 Storage:Store at -20℃ Remarks Nicotinamide Mononucleotide, also known as ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that

Chemical Information Product name:Methyl 1,2,4-Triazole-3-carboxylate Purity:98% min CAS NO:4928-88-5 Solubility:Soluble in DMSO Molecular Formula:C4H5N3O2 Package:Package according to customer requirements. Molecular Weight:127.1 Storage:-20ºC Remarks Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent. Properties: Melting point: 196-199 °C(lit.) Boiling point:

Chemical Information Product name:Indoline-2-carboxylic acid Purity:98% min CAS NO:78348-24-0 Solubility:Soluble in DMSO Molecular Formula:C9H9NO2 Package:Package according to customer requirements. Molecular Weight:163.173 Storage:-20ºC Remarks Synonyms: Indoline-2-carboxylate acid; Indoline-2-carboxylicacid; Indoline-2-carboxylicac; DL-INDOLINE-2-CARBOXYLIC ACID; Indoline-2-carboxykicacid; Properties: Appearance & Physical State: Solid. Density: 1.286 g/cm3 Boiling Point:

Chemical Information Product name:Cicloheximide Actidione Purity:98% min CAS NO:66-81-9 Solubility:DMSO: ≥ 33 mg/mL; H2O: 20 mg/mL Molecular Formula:C15H23NO4 Package:Package according to customer requirements Molecular Weight:281.347 Storage: Store at -20℃ Remarks Cycloheximide (CHX) is the most common laboratory reagent used to inhibit protein synthesis. Cycloheximide has been shown to block the elongation phase of eukaryotic translation. Cycloheximide binds the ribosome