Synthesis Inhibitors

Chemical Information Product name:CI-719 Gemfibrozil Purity:98% min CAS NO:25812-30-0 Solubility:DMSO : ≥ 34 mg/mL (135.82 mM) Molecular Formula:C15H22O3 Package:Package according to customer requirements Molecular Weight:250.333 Storage:Store at -20℃ Quality control COA Remarks Gemfibrozil is a peroxisome proliferator receptor alpha agonist. The mechanism of action of gemfibrozil is as a Peroxisome Proliferator-activated Receptor alpha Agonist. The chemical classification of

Chemical Information Product name:Tubastatin A HCl Purity:98% min CAS NO:1310693-92-5 Solubility:DMSO : 10.8 mg/mL (29.04 mM) Molecular Formula:C20H22ClN3O2 Package:Package according to customer requirements. Molecular Weight:371.861 Storage:Store at -20℃ Quality control COA Remarks Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was

Chemical Information Product name:Sarolaner Purity:98.0% min CAS NO:1398609-39-6 Solubility:DMSO : 150 mg/mL (258.02 mM; Need ultrasonic) Molecular Formula:C23H18Cl2F4N2O5S Package:Package according to customer requirements Molecular Weight:581.364 Storage:Store at -20℃ Remarks Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O.

Chemical Information Product name:CD38 inhibitor 78c Purity:98.0% min CAS NO:1700637-55-3 Solubility:DMSO : 35.71 mg/mL (86.35 mM; Need ultrasonic) Molecular Formula:C22H27N3O3S Package:Package according to customer requirements Molecular Weight:413.533 Storage:Store at -20℃ Remarks CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively. In vitro: CD38 inhibitor 1 (compound

Chemical Information Product name:Inarigivir soproxil SB9200 Purity:98.0% min CAS NO:942123-43-5 Solubility:DMSO : ≥ 102 mg/mL (144.96 mM) Molecular Formula:C25H34N7O13PS Package:Package according to customer requirements Molecular Weight:703.615 Storage:Store at -20℃ Remarks Inarigivir soproxil, also known as SB 9200, is an antiviral agent. SB 9200 is also a novel agonist of innate immunity, which shows potent antiviral activity against resistant HCV variants. SB 9200 has

Chemical Information Product name:Selpercatinib LOXO-292 Purity:98.0% min CAS NO:2152628-33-4 Solubility:DMSO : 62.5 mg/mL (118.91 mM) Molecular Formula:C29H31N7O3 Package:Package according to customer requirements Molecular Weight:525.602 Storage:Store at -20℃ Remarks Selpercatinib, also known as LOXO-292, is a potent and selective RET inhibitor with antineoplastic properties. LOXO-292 selectively binds to and targets various RET mutants and RET-containing fusion products.

Chemical Information Product name:JRF-12 DBeQ Purity:98% min CAS NO:177355-84-9 Solubility:DMSO : ≥ 47 mg/mL (138.06 mM) Molecular Formula:C22H20N4 Package:Package according to customer requirements Molecular Weight:340.421 Storage:Store at -20℃ Quality control COA Remarks DBeQ, also known as JRF 12, is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 for treatment of cancer. DBeQ impairs both ubiquitin-dependent and autophagic protein clearance

Chemical Information Product name:Fotemustine Purity:98% min CAS NO:92118-27-9 Solubility:DMSO : ≥ 3.2 mg/mL (10.14 mM) Molecular Formula:C9H19ClN3O5P Package:Packaging according to customer requirements Molecular Weight:315.691 Storage:Store at -20℃ Remarks Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages

Chemical Information Product name:Buparlisib hydrochloride Purity:98% min CAS NO:1312445-63-8 Solubility:DMSO : ≥ 50 mg/mL (111.89 mM) Molecular Formula:C18H22ClF3N6O2 Package:Package according to customer requirements Molecular Weight:446.854 Storage:Store at -20℃ Remarks Buparlisib, also known as BKM120, is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity.

Chemical Information Product name:Clofarabine Purity:98% min CAS NO:123318-82-1 Solubility:DMSO : ≥ 50 mg/mL (164.65 mM) Molecular Formula:C10H11ClFN5O3 Package:Package according to customer requirements Molecular Weight:303.677 Storage:Store at -20℃ Quality control COA Remarks Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which

Chemical Information Product name:Epigoitrin Purity:98.0% min CAS NO:1072-93-1 Solubility:DMSO : 50 mg/mL (387.06 mM) Molecular Formula:C5H7NOS Package:Package according to customer requirements. Molecular Weight:129.18 Storage:Store at -20℃ Remarks Epigoitrin is the main bioactive constituent of an important traditional Chinese herbal medicine, Radix isatidis. The pharmacological effects of epigoitrin include antiviral, anticancer, and antithyroid activities. Synonyms: 5

Chemical Information Product name:Decoglurant Purity:98% min CAS NO:911115-16-7 Solubility:DMSO : 250 mg/mL (558.86 mM) Molecular Formula:C21H11F6N5 Package:Package according to customer requirements. Molecular Weight:447.336 Storage:Store at -20℃ Remarks Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant

Chemical Information Product name:KGA-2727 Purity:98.0% min CAS NO:666842-36-0 Solubility:DMSO : 100 mg/mL (186.35 mM; Need ultrasonic) Molecular Formula:C26H40N4O8 Package:Package according to customer requirements Molecular Weight:536.63 Storage:Store at -20℃ Remarks KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for

Chemical Information Product name:MK-0591 Quiflapon Purity:98.0% min CAS NO:136668-42-3 Solubility:DMSO : ≥ 50 mg/mL (85.15 mM) Molecular Formula:C34H35ClN2O3S Package:Package according to customer requirements Molecular Weight:587.171 Storage:Store at -20℃ Remarks Quiflapon, also known as MK 0591, is a potent and selective 5-Lipoxygenase-activating protein (FLAP) inhibitor. MK-0591 is also a potent inhibitor of leukotriene (LT) biosynthesis in intact human and elicited rat

Chemical Information Product name:Nusinersen Purity:98% min CAS NO:1258984-36-9 Solubility:Soluble in DMSO Molecular Formula:C234H340N61O128P17S17 Package:Package according to customer requirements Molecular Weight:7127.194237 Storage:Store at -20℃ Remarks Nusinersen is an antisense oligonucleotide that induces SMN protein expression. Nusinersen was developed in 2016 for the treatment of spinal muscular atrophy (SMA), a rare neuromuscular disorder. Synonyms: RNA [2'-O-(2

Chemical Information Product name:Sotorasib (AMG510) Purity:98% min CAS NO:2296729-00-3 Solubility:DMSO : 50 mg/mL (89.19 mM; Need ultrasonic) Molecular Formula:C30H30F2N6O3 Package:Packaging according to customer requirements. Molecular Weight:560.594 Storage:Store at -20℃ Remarks Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.

Chemical Information Product name:Calcium N5-methyltetrahydrofolate Purity:98% min CAS NO:26560-38-3 Solubility:Soluble in DMSO Molecular Formula:C20H25CaN7O6++ Package:Package according to customer requirements. Molecular Weight:499.534 Storage:-20ºC Remarks Calcium methyltetrahydrofolate is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate. It is synthesized by reduction of folic acid to tetrahydrofolic acid followed by methylation

Chemical Information Product name:(S)-Indoline-2-carboxylic Acid Purity:98% min CAS NO:79815-20-6 Solubility:Soluble in DMSO Molecular Formula:163.173 Package:Package according to customer requirements. Molecular Weight:49.33 Storage:-20ºC Remarks Synonyms: (R)-1H-INDOLE-2-CARBOXYLIC ACID; (R)-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID; (R)-(+)-2,3-DIHYDROINDOLE-2-CARBOXYLIC ACID; Perindopril Intermediate; (2S)-indoline-2-carboxylic acid; Properties: Appearance & Physical State:

Chemical Information Product name:2-Thiopheneacetyl chloride Purity:98% min CAS NO:39098-97-0 Solubility:Soluble in DMSO Molecular Formula:C6H5ClOS Package:Package according to customer requirements. Molecular Weight:160.62 Storage:-20ºC Remarks 2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis

Chemical Information Product name:tert-Butyl 1-piperazinecarboxylate Purity:98% min CAS NO:57260-71-6 Solubility:Soluble in DMSO Molecular Formula:C9H18N2O2 Package:Package according to customer requirements. Molecular Weight:186.251 Storage:-20ºC Remarks N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). Synonyms: piperazine-1-carboxylic acid tert-butyl ester; BOC-PIPERAZINE; 1-Boc piperzine; t