Synthesis Inhibitors

Chemical Information Product name:IPI-145 Duvelisib Purity:98% min CAS NO:1201438-56-3 Solubility:DMSO : ≥ 41 mg/mL (98.35 mM) Molecular Formula:C22H17ClN6O Package:Package according to customer requirements Molecular Weight:416.863 Storage:Store at -20℃ Remarks Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential

Chemical Information Product name:IPI-145 Duvelisib Purity:98% min CAS NO:1201438-56-3 Solubility:DMSO : ≥ 41 mg/mL (98.35 mM) Molecular Formula:C22H17ClN6O Package:Package according to customer requirements Molecular Weight:416.863 Storage:Store at -20℃ Remarks Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential

Chemical Information Product name:PHA-665752 Purity:98% min CAS NO:477575-56-7 Solubility:DMSO : 50 mg/mL (77.93 mM) Molecular Formula:C32H34Cl2N4O4S Package:Package according to customer requirements Molecular Weight:641.608 Storage:Store at -20℃ Remarks PHA665752 is a potent and selective inhibitor of c-Met/HGF/SF (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively). PHA-665752 suppresses the hepatocyte

Chemical Information Product name:Belumosudil (KD025) Purity:98% min CAS NO:911417-87-3 Solubility:DMSO : ≥ 29 mg/mL (64.09 mM) Molecular Formula:C26H24N6O2 Package:Package according to customer requirements Molecular Weight:452.508 Storage:Store at -20℃ Remarks Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM

Chemical Information Product name:M344 Purity:98% min CAS NO:251456-60-7 Solubility:DMSO : ≥ 100 mg/mL (325.32 mM) Molecular Formula:C16H25N3O3 Package:Package according to customer requirements Molecular Weight:307.388 Storage:Store at -20℃ Remarks M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs. Properties: Density: 1

Chemical Information Product name:ABT-751 Purity:98% min CAS NO:141430-65-1 Solubility:DMSO : ≥ 48 mg/mL (129.24 mM) Molecular Formula:C18H17N3O4S Package:Package according to customer requirements Molecular Weight:371.410 Storage:Store at -20℃ Remarks ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. IC50 Value: 1.5 μM(neuroblastoma); 3.4

Chemical Information Product name:PCI-24781 Abexinostat Purity:98% min CAS NO:783355-60-2 Solubility:Soluble in DMSO Molecular Formula:C21H23N3O5 Package:Package according to customer requirements Molecular Weight:397.424 Storage:Store at -20℃ Remarks Abexinostat, also known as PCI-24781 or CRA-024781, is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC,

Chemical Information Product name:Lornoxicam Purity:98% min CAS NO:70374-39-9 Solubility:DMSO: 3.7 mg/mL Molecular Formula:C13H10ClN3O4S2 Package:Package according to customer requirements Molecular Weight:371.819 Storage:Store at -20℃ Remarks Lornoxicam is a new nonsteroidal anti-inflammatory drug of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin

Chemical Information Product name:MK-5108 VX-689 Purity:98% min CAS NO:1010085-13-8 Solubility:DMSO : 6.4 mg/mL (13.85 mM) Molecular Formula:C22H21ClFN3O3S Package:Package according to customer requirements Molecular Weight:461.937 Storage:Store at -20℃ Remarks MK-5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora-A kinase. MK-5108 specifically inhibited Aurora-A kinase in a panel of protein kinase assays. MK-5108 also induced

Chemical Information Product name:CI-994 Tacedinaline Purity:98% min CAS NO:112522-64-2 Solubility:DMSO : ≥ 58 mg/mL (215.37 mM) Molecular Formula:C15H15N3O2 Package:Package according to customer requirements Molecular Weight:269.299 Storage:Store at -20℃ Remarks Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells.

Chemical Information Product name:GNE-6776 Purity:98% min CAS NO:2009273-71-4 Solubility:DMSO : ≥ 310 mg/mL (889.78 mM) Molecular Formula:C20H20N4O2 Package:Package according to customer requirements Molecular Weight:348.40 Storage:Store at -20℃ Remarks GNE-6776 non-covalently targets USP7 12 Å distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen

Chemical Information Product name:Trilaciclib Purity:98% min CAS NO:1374743-00-6 Solubility:Soluble in DMSO Molecular Formula:C24H30N8O Package:Package according to customer requirements. Molecular Weight:446.55 Storage:-20ºC Remarks Trilaciclib is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. Synonyms: 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro(cyclohexane-1,9'-pyrazino(1',2':1,5)pyrrolo(2,3-d)pyrimidin)-6'

Name Cerivastatin sodium CAS NO. 143201-11-0 Molecular Formula C26H34FNO5 Molecular Weight 459.55 Standard Assay ≥99% Structure Remarks Order None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

Chemical Information Product name:Vinorelbine Tartrate Purity:98% min CAS NO:125317-39-7 Solubility:DMSO : ≥ 46 mg/mL (42.63 mM) Molecular Formula:C53H66N4O20 Package:Package according to customer requirements Molecular Weight:1079.11 Storage:Store at -20℃ Remarks Vinorelbine is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into

Chemical Information Product name:Mizoribine Purity:98% min CAS NO:50924-49-7 Solubility:DMSO: ≥ 35 mg/mL Molecular Formula:C9H13N3O6 Package:Package according to customer requirements Molecular Weight:259.2160 Storage:Store at -20℃ Quality control COA Remarks Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum.

Chemical Information Product name:RepSox Purity:98.0% min CAS NO:446859-33-2 Solubility:DMSO : 33.33 mg/mL (116.00 mM) Molecular Formula:C17H13N5 Package:Package according to customer requirements Molecular Weight:287.32 Storage:Store at -20℃ Remarks RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively. Properties

Chemical Information Product name:EGFR-IN-7 Purity:98% min CAS NO:2267329-76-8 Solubility:DMSO : 5 mg/mL (7.20 mM) Molecular Formula:C32H41BrN9O2P Package:Package according to customer requirements. Molecular Weight:694.6 Storage:-20ºC Remarks TQB3804, also known as EGFR-IN-7, is a selective and potent EGFR kinase inhibitor. TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0

Chemical Information Product name:Famciclovir Purity:98% min CAS NO:104227-87-4 Solubility:DMSO : ≥ 100 mg/mL (311.21 mM) Molecular Formula:C14H19N5O4 Package:Package according to customer requirements. Molecular Weight:321.332 Storage:-20ºC Remarks Famciclovir (INN) is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is also indicated for treatment of recurrent episodes of herpes

Chemical Information Product name:Levomefolate calcium Purity:98% min CAS NO:151533-22-1 Solubility:H2O : 4.4 mg/mL (8.84 mM) Molecular Formula:C20H23CaN7O6 Package:Package according to customer requirements. Molecular Weight:497.518 Storage:-20ºC Remarks Levomefolate calcium, also known as LMCA and BAY 86-7660, is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12 , as a methyl-group

Chemical Information Product name:TP-2 TV-EDI Purity:98% min CAS NO:53872-60-9 Solubility:Soluble in DMSO Molecular Formula:C18H19F3O5 Package:Package according to customer requirements Molecular Weight:372.336 Storage:Store at -20℃ Remarks Chemical Name: (3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one Properties: Density: 1.434 g/cm3 Boiling Point: 520.599ºC at 760 mmHg Refractive Index: 1