Synthesis Inhibitors

Chemical Information Product name:Misoprostol Purity:98% min CAS NO:59122-46-2 Solubility:DMSO: 6.4 mg/mL Molecular Formula:C22H38O5 Package:Package according to customer requirements. Molecular Weight:382.534 Storage:Store at -20℃ Quality control COA Remarks Misoprostol is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus. For abortions it is often used with mifepristone

Chemical Information Product name:EMA400 Purity:98% min CAS NO:152362-51-1 Solubility: Molecular Formula:C32H29NO5 Package:Package according to customer requirements Molecular Weight:507.576 Storage:Store at -20℃ Remarks EMA400 is a potent and highly selective AT2R antagonist. The angiotensin II type 2 (AT2) receptor is a target with promising data in rodent models of peripheral neuropathic pain. References 1: Anand U, Yiangou Y, Sinisi M, Fox M, MacQuillan A, Quick T,

Chemical Information Product name:1A-116 Purity:99% min CAS NO:1430208-73-3 Solubility:DMSO : 100 mg/mL (325.40 mM) Molecular Formula:C16H16F3N3 Package:Package according to customer requirements Molecular Weight:307.32 Storage:Store at -20℃ Remarks 1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer. 1A-116 prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes .

Chemical Information Product name:VPS34 inhibitor 1 Purity:99% min CAS NO:1383716-46-8 Solubility:78 mg/mL (199.24 mM) Molecular Formula:C21H25N7O Package:Package according to customer requirements Molecular Weight:391.47 Storage:Store at -20℃ Remarks VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. In vitro: Compound 19 is extraordinarily selective over other lipid and protein kinases. The ability of

Chemical Information Product name:GSK3787 Purity:98% min CAS NO:188591-46-0 Solubility:DMSO : ≥ 50 mg/mL (127.30 mM); H2O : < 0.1 mg/mL Molecular Formula:C15H12ClF3N2O3S Package:Package according to customer requirements Molecular Weight:392.781 Storage:Store at -20℃ Remarks GSK-3787 is a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist with good pharmacokinetic properties. GSK3787 can antagonize PPARbeta/delta in vivo, thus

Chemical Information Product name:SNS-314 Purity:98% min CAS NO:1057249-41-8 Solubility:DMSO : 50 mg/mL (94.87 mM) Molecular Formula:C19H19ClN6O4S3 Package:Package according to customer requirements Molecular Weight:527.040 Storage:Store at -20℃ Remarks SNS-314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of

Chemical Information Product name:CD271 Adapalene Purity:98% min CAS NO:106685-40-9 Solubility:DMSO : 20 mg/mL (48.48 mM) Molecular Formula:C28H28O3 Package:Package according to customer requirements Molecular Weight:412.52 Storage:Store at -20℃ Quality control COA Remarks Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respective

Chemical Information Product name:AT13387 Onalespib Purity:98% min CAS NO:912999-49-6 Solubility:DMSO : ≥ 33 mg/mL (80.58 mM) Molecular Formula:C24H31N3O3 Package:Package according to customer requirements Molecular Weight:409.521 Storage:Store at -20℃ Remarks Onalespib, also known as AT13387 , is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to

Chemical Information Product name:Carfilzomib intermediate Purity:98% min CAS NO:247068-85-5 Solubility:Soluble in DMSO Molecular Formula:C11H18F3NO4 Package:Package according to customer requirements. Molecular Weight:285.26 Storage:Store at -20℃ Remarks Chemical Name: (S)-2-Amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one 2,2,2-trifluoroacetate Synonyms: PR171 intermediate; 1-Pentanone, 2-amino-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-, (2S)-, 2,2,2-trifluoroacetate (1:1

Chemical Information Product name:SRT1720 hcl Purity:98% min CAS NO:1001645-58-4 Solubility:DMSO: 100 mg/mL (197.62 mM) Molecular Formula:C25H24ClN7OS Package:Package according to customer requirements Molecular Weight:506.022 Storage:Store at -20℃ Remarks SRT-1720, also known as CAY10559 and is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body to the known SIRT1 activator

Chemical Information Product name:MK-8745 Purity:98% min CAS NO:885325-71-3 Solubility:DMSO : ≥ 34 mg/mL (78.72 mM) Molecular Formula:C20H19ClFN5OS Package:Package according to customer requirements Molecular Weight:431.914 Storage:Store at -20℃ Remarks MK-8745 is a novel Aurora-A specific inhibitor. MK8745 induced apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK8745 resulted in the

Chemical Information Product name:TAK-901 Purity:98% min CAS NO:934541-31-8 Solubility:DMSO : 2 mg/mL (3.96 mM) Molecular Formula:C28H32N4O3S Package:Package according to customer requirements Molecular Weight:504.644 Storage:Store at -20℃ Remarks TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease

Chemical Information Product name:Volasertib BI6727 Purity:98% min CAS NO:755038-65-4 Solubility:DMSO : 50 mg/mL (80.80 mM) Molecular Formula:C34H50N8O3 Package:Package according to customer requirements Molecular Weight:618.813 Storage:Store at -20℃ Remarks Volasertib, also known as BI-6727, is a dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. BI 6727 selectively inhibits Plk1, inducing selective G2/M arrest followed by

Chemical Information Product name:MK-0683 Vorinostat Purity:98% min CAS NO:149647-78-9 Solubility:DMSO: ≥ 100 mg/mL Molecular Formula:C14H20N2O3 Package:Package according to customer requirements Molecular Weight:264.320 Storage:Store at -20℃ Quality control COA Remarks Vorinostat, also known as suberanilohydroxamic acid, MK-0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone

Chemical Information Product name:Vinblastine sulfate Purity:98% min CAS NO:143-67-9 Solubility:DMSO : ≥ 44 mg/mL (48.40 mM) Molecular Formula:C46H60N4O13S Package:Package according to customer requirements Molecular Weight:909.053 Storage:Store at -20℃ Quality control COA Remarks Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and

Chemical Information Product name:KU-57788 NU7441 Purity:98% min CAS NO:503468-95-9 Solubility:DMSO : 14.29 mg/mL (34.56 mM) Molecular Formula:C25H19NO3S Package:Package according to customer requirements. Molecular Weight:413.488 Storage:Store at -20℃ Quality control COA Remarks NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation

Chemical Information Product name:Hesperadin Purity:98% min CAS NO:422513-13-1 Solubility:DMSO: 100 mg/mL (193.55 mM) Molecular Formula:C29H32N4O3S Package:Package according to customer requirements Molecular Weight:516.654 Storage:Store at -20℃ Remarks Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked

Chemical Information Product name:GNE-493 Purity:98% min CAS NO:1033735-94-2 Solubility:DMSO : ≥ 45 mg/mL (120.82 mM) Molecular Formula:C17H20N6O2S Package:Package according to customer requirements Molecular Weight:372.445 Storage:Store at -20℃ Remarks GNE-493 is a low molecular weight, potent dual inhibitor of pan-PI3 kinases and mTOR. GNE-493 displays approximately equipotent inhibition of Class I PI3K isoforms, is submitted for screening in a 142 kinase panel provided by

Chemical Information Product name:MTX-211 Purity:98% min CAS NO:1952236-05-3 Solubility:DMSO : ≥ 100 mg/mL (209.06 mM) Molecular Formula:C20H14Cl2FN5O2S Package:Package according to customer requirements Molecular Weight:478.327 Storage:Store at -20℃ Remarks MTX-211 is a dual inhibitor of EGFR and PI3K. MTX-211 is potentially useful for treatment of KRAS mutant colorectal cancer. Related Products: Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK

Chemical Information Product name:GSK-923295 Purity:98.0% min CAS NO:1088965-37-0 Solubility:DMSO : 30 mg/mL (50.66 mM; Need ultrasonic) Molecular Formula:C32H38ClN5O4 Package:Package according to customer requirements. Molecular Weight:592.128 Storage:-20℃ Remarks GSK-923295, also known as GSK-923295A, is a novel antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK923295A demonstrated significant antitumor activity against