Synthesis Inhibitors

Chemical Information Product name:CTP-354 Purity:98.0% min CAS NO:1213669-91-0 Solubility:Soluble in DMSO Molecular Formula:C19H10D9F2N7O Package:Package according to customer requirements Molecular Weight:408.453 Storage:Store at -20℃ Remarks CTP354, also known as C-21191, a novel deuterated subtype-selective GABA(A) modulator. CTP may be potentially useful for treatment of neuropathic pain, spasticity and anxiety disorders. GABAA receptors are found in the nervous system

Chemical Information Product name:Edicotinib Purity:98% min CAS NO:1142363-52-7 Solubility:DMSO : 16.67 mg/mL (36.11 mM) Molecular Formula:C27H35N5O2 Package:Package according to customer requirements Molecular Weight:461.599 Storage:Store at -20℃ Remarks Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3

Chemical Information Product name:Bempedoic acid Purity:98% min CAS NO:738606-46-7 Solubility:DMSO : 100 mg/mL (290.28 mM) Molecular Formula:C19H36O5 Package:Package according to customer requirements Molecular Weight:344.486 Storage:Store at -20℃ Remarks Bempedoic acid, also known as ESP-55016 and ETC-1002, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C

Chemical Information Product name:Ornoprostil Purity:98% min CAS NO:70667-26-4 Solubility:Soluble in DMSO Molecular Formula:C23H38O6 Package:Package according to customer requirements Molecular Weight:410.544 Storage:Store at -20℃ Remarks Ornoprostil is a prostaglandin E1 analogue that acts as a mucosal protectant. Properties: Density: 1.112g/cm3 Boiling Point: 549.8ºC at 760 mmHg Flash Point: 178.8ºC Refractive Index: 1.526 Prostaglandins Related Products: TP-2(TV-EDI);

Chemical Information Product name:RDC-3317 Aripiprazole lauroxil Purity:98% min CAS NO:1259305-29-7 Solubility: Molecular Formula:C36H51Cl2N3O4 Package:Package according to customer requirements Molecular Weight:660.714 Storage:Store at -20℃ Remarks Aripiprazole lauroxil, aslo known as RDC 3317, is a long-acting injectable atypical antipsychotic. It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to six weeks for

Chemical Information Product name:AY-62022 Medrogestone Purity:98% min CAS NO:977-79-7 Solubility:Soluble in DMSO Molecular Formula:C23H32O2 Package:Package according to customer requirements Molecular Weight:340.499 Storage:Store at -20℃ Remarks Medrogestone is a progestin that has been used in hormone replacement therapy for menopausal symptoms and in the treatment of gynecological disorders. Properties: Density: 1.08g/cm3 Boiling Point: 467.2ºC at 760mmHg Flash Point: 173

Chemical Information Product name:trans-Latanoprost Purity:95%min CAS NO:913258-34-1 Solubility:Soluble in DMSO Molecular Formula:C26H40O5 Package:Packaging according to customer requirements. Molecular Weight:432.59 Storage:Store at -20℃ Quality control COA Remarks Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has

Chemical Information Product name:P005091 Purity:98% min CAS NO:882257-11-6 Solubility:DMSO : 50 mg/mL (143.59 mM) Molecular Formula:C12H7Cl2NO3S2 Package:Package according to customer requirements Molecular Weight:348.225 Storage:Store at -20℃ Remarks P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μ M). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo . The deubiquityl

Chemical Information Product name:Martha calciferol CD ring Purity:98% min CAS NO:192573-33-4 Solubility:Soluble in DMSO Molecular Formula:C20H38O3Si Package:Package according to customer requirements. Molecular Weight:354.599 Storage:-20ºC Remarks Chemical Name: (1S,3aR,7aR)-1-[(S)-1-(3-methyl-3-trimethylsilyloxybutyloxy)ethyl]-7a-methyloctahydro-1H-inden-4-one Synonyms: (1S,3aR,7aR)-7a-Methyl-1-[(S)-1-(3-methyl-3-trimethylsilanyloxy-butoxy)-ethyl]-octahydro-inden-4-one; de

Chemical Information Product name:Beraprost sodium Purity:99% min CAS NO:88475-69-8 Solubility:Soluble in DMSO Molecular Formula:C24H29NaO5 Package:Packaging according to customer requirements Molecular Weight:420.47 Storage:Store at -20℃ Quality control COA Remarks Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and

Chemical Information Product name:Tenovin-6 HCl Purity:98% min CAS NO:1011301-29-3 Solubility:DMSO : ≥ 49 mg/mL (99.78 mM) Molecular Formula:C25H35ClN4O2S Package:Package according to customer requirements Molecular Weight:491.089 Storage:Store at -20℃ Remarks Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the

Chemical Information Product name:unoprostone Purity:98% min CAS NO:120373-36-6 Solubility:Soluble in DMSO Molecular Formula:C22H38O5 Package:Package according to customer requirements Molecular Weight:382.53 Storage:Store at -20℃ Quality control Remarks Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used

Chemical Information Product name:Bendamustine hydrochloride Purity:98% min CAS NO:3543-75-7 Solubility:DMSO : 100 mg/mL (253.34 mM) Molecular Formula:C16H22Cl3N3O2 Package:Package according to customer requirements Molecular Weight:394.724 Storage:Store at -20℃ Quality control COA Remarks Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three

Chemical Information Product name:INNO-206 HCl salt Purity:98% min CAS NO:480998-12-7 Solubility:DMSO : 125 mg/mL (158.79 mM) Molecular Formula:C37H43ClN4O13 Package:Package according to customer requirements. Molecular Weight:787.209 Storage:Store at -20℃ Remarks Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the

Chemical Information Product name:CP671305 Purity:98% min CAS NO:445295-04-5 Solubility:DMSO : ≥ 160 mg/mL (352.11 mM) Molecular Formula:C23H19FN2O7 Package:Package according to customer requirements Molecular Weight:454.4 Storage:Store at -20℃ Remarks CP-671305 is a potent, selective and orally active inhibitor of phosphodiesterase-4-D (PDE4-D) with IC50 of 3 nM. In Vitro: CP-671,305 is identified as a substrate of MRP2 and BCRP, but not MDR1. CP-671,305 is a substrate of

Chemical Information Product name:PK11000 Purity:99% min CAS NO:38275-34-2 Solubility:DMSO : 100 mg/mL (422.60 mM) Molecular Formula:C6H5ClN2O4S Package:Package according to customer requirements Molecular Weight:236.633 Storage:Store at 2-8°C Remarks PK11000 is a mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53. It effectively kills cancer cells, especially with null or mutant p53 background, and shows

Chemical Information Product name:CUDC-907 fimepinostat Purity:98% min CAS NO:1339928-25-4 Solubility:DMSO : ≥ 50 mg/mL (98.32 mM) Molecular Formula:C23H24N8O4S Package:Package according to customer requirements Molecular Weight:508.553 Storage:Store at -20℃ Quality control COA Remarks CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplas

Chemical Information Product name:AZD8186 Purity:99% min CAS NO:1627494-13-6 Solubility:DMSO : ≥ 35 mg/mL (76.51 mM) Molecular Formula:C24H25F2N3O4 Package:Package according to customer requirements Molecular Weight:457.470 Storage:Store at -20℃ Remarks AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the

Chemical Information Product name:Nintedanib (BIBF 1120) Purity:99% min CAS NO:656247-17-5 Solubility:DMSO : 20 mg/mL (37.06 mM) Molecular Formula:C31H33N5O4 Package:Packaging according to customer requirements. Molecular Weight:539.62 Storage:Store at -20℃ Quality control COA Remarks BIBF 1120 is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.Nintedanib (BIBF 1120)

Chemical Information Product name:Ponatinib AP24534 Purity:98% min CAS NO:943319-70-8 Solubility:DMSO : ≥ 50 mg/mL (93.89 mM) Molecular Formula:C29H27F3N6O Package:Packaging according to customer requirements. Molecular Weight:532.56 Storage:Store at -20℃ Quality control COA Remarks Ponatinib is a potent, orally available multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.Ponatinib